Biliverdin is a green pigment formed as a byproduct of heme breakdown. It consists of four linearly connected pyrrole rings (a tetrapyrrole). Biliverdin is formed when a heme prosthetic group is cleaved at its α-methine bridge. The resulting water-soluble biliverdin (C33H34N4O6) is then converted to bilirubin (C33H36N4O6) by biliverdin reductase in macrophages of the reticuloendothelial system. The changing color of a bruise from deep purple to yellow over time is a graphical indicator of this reaction.
Biliverdin is also present in the bile juice which is secreted by the liver and also imparts color to the bile juice.
The green-blooded skinks of the genus Prasinohaema possess such high (and would otherwise be toxic) levels of biliverdin in their blood that their tissues are colored a bright green.
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Tetrapyrroles
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