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CACNB1 

Calcium channel, voltage-dependent, beta 1 subunit
PDB rendering based on 1t0h.
Available structures: 1t0h, 1t0j
Identifiers
Symbols CACNB1; CAB1; CACNLB1; CCHLB1; MGC41896
External IDs OMIM: 114207 MGI: 102522 HomoloGene: 20186
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 782 12295
Ensembl ENSG00000067191 ENSMUSG00000020882
Uniprot Q02641 Q6DD95
Refseq NM_000723 (mRNA)
NP_000714 (protein)		 XM_978622 (mRNA)
XP_983716 (protein)
Location Chr 17: 34.58 - 34.61 Mb Chr 11: 97.82 - 97.84 Mb
Pubmed search [1] [2]

Calcium channel, voltage-dependent, beta 1 subunit, also known as CACNB1, is a human gene.[1]

The protein encoded by this gene belongs to the calcium channel beta subunit family. It plays an important role in the calcium channel by modulating G protein inhibition, increasing peak calcium current, controlling the alpha-1 subunit membrane targeting and shifting the voltage dependence of activation and inactivation. Alternative splicing occurs at this locus and three transcript variants encoding three distinct isoforms have been identified.[1]

Contents

See also

References

  1. ^ a b "Entrez Gene: CACNB1 calcium channel, voltage-dependent, beta 1 subunit".

Further reading

  • Williams ME, Feldman DH, McCue AF, et al. (1992). "Structure and functional expression of alpha 1, alpha 2, and beta subunits of a novel human neuronal calcium channel subtype.". Neuron 8 (1): 71–84. PMID 1309651. 
  • Perez-Reyes E, Castellano A, Kim HS, et al. (1992). "Cloning and expression of a cardiac/brain beta subunit of the L-type calcium channel.". J. Biol. Chem. 267 (3): 1792–7. PMID 1370480. 
  • Powers PA, Liu S, Hogan K, Gregg RG (1992). "Skeletal muscle and brain isoforms of a beta-subunit of human voltage-dependent calcium channels are encoded by a single gene.". J. Biol. Chem. 267 (32): 22967–72. PMID 1385409. 
  • Pragnell M, Sakamoto J, Jay SD, Campbell KP (1991). "Cloning and tissue-specific expression of the brain calcium channel beta-subunit.". FEBS Lett. 291 (2): 253–8. PMID 1657644. 
  • Collin T, Wang JJ, Nargeot J, Schwartz A (1993). "Molecular cloning of three isoforms of the L-type voltage-dependent calcium channel beta subunit from normal human heart.". Circ. Res. 72 (6): 1337–44. PMID 7916667. 
  • Gregg RG, Powers PA, Hogan K (1993). "Assignment of the human gene for the beta subunit of the voltage-dependent calcium channel (CACNLB1) to chromosome 17 using somatic cell hybrids and linkage mapping.". Genomics 15 (1): 185–7. doi:10.1006/geno.1993.1029. PMID 8381767. 
  • Iles DE, Segers B, Sengers RC, et al. (1993). "Genetic mapping of the beta 1- and gamma-subunits of the human skeletal muscle L-type voltage-dependent calcium channel on chromosome 17q and exclusion as candidate genes for malignant hyperthermia susceptibility.". Hum. Mol. Genet. 2 (7): 863–8. PMID 8395940. 
  • Fukuda K, Kaneko S, Yada N, et al. (1997). "Cyclic AMP-dependent modulation of N- and Q-type Ca2+ channels expressed in Xenopus oocytes.". Neurosci. Lett. 217 (1): 13–6. PMID 8905728. 
  • Gregg RG, Messing A, Strube C, et al. (1997). "Absence of the beta subunit (cchb1) of the skeletal muscle dihydropyridine receptor alters expression of the alpha 1 subunit and eliminates excitation-contraction coupling.". Proc. Natl. Acad. Sci. U.S.A. 93 (24): 13961–6. PMID 8943043. 
  • Brice NL, Dolphin AC (1999). "Differential plasma membrane targeting of voltage-dependent calcium channel subunits expressed in a polarized epithelial cell line.". J. Physiol. (Lond.) 515 ( Pt 3): 685–94. PMID 10066897. 
  • Lie AA, Blümcke I, Volsen SG, et al. (1999). "Distribution of voltage-dependent calcium channel beta subunits in the hippocampus of patients with temporal lobe epilepsy.". Neuroscience 93 (2): 449–56. PMID 10465427. 
  • Hogan K, Greg RG, Powers PA (2000). "Structure and alternative splicing of the gene encoding the human beta1 subunit of voltage dependent calcium channels.". Neurosci. Lett. 277 (2): 111–4. PMID 10624822. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Finlin BS, Crump SM, Satin J, Andres DA (2004). "Regulation of voltage-gated calcium channel activity by the Rem and Rad GTPases.". Proc. Natl. Acad. Sci. U.S.A. 100 (24): 14469–74. doi:10.1073/pnas.2437756100. PMID 14623965. 
  • Navarro-Lérida I, Martínez Moreno M, Roncal F, et al. (2004). "Proteomic identification of brain proteins that interact with dynein light chain LC8.". Proteomics 4 (2): 339–46. doi:10.1002/pmic.200300528. PMID 14760703. 
  • Foell JD, Balijepalli RC, Delisle BP, et al. (2004). "Molecular heterogeneity of calcium channel beta-subunits in canine and human heart: evidence for differential subcellular localization.". Physiol. Genomics 17 (2): 183–200. doi:10.1152/physiolgenomics.00207.2003. PMID 14762176. 
  • Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.". Cell 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. 
  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. 

External links

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v • d • e
Membrane transport protein: ion channels
Ca2+: Calcium channel
L-type/Cavα (1.1, 1.2, 1.3, 1.4) • N-type/Cavα2.2 • P-type/Cavα(2.1) • Q-type/Cavα2.1 • R-type/Cavα2.3 • T-type/Cavα(3.2)
α2δ-subunits (1, 2) • β-subunits (β1, β2, β3, β4) • γ-subunits (γ1, γ2, γ3, γ4)
Other
Na+: Sodium channel
Navα (1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.8, 1.9, 7A) • Navβ (1, 2, 3, 4)
Other
K+: Potassium channel
Kvα (1-6) (1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.10, 2.1, 2.2, 3.1, 3.2, 3.3, 3.4, 4.1, 4.2, 4.3, 5.1, 6.1, 6.2, 6.3, 6.4)
Kvα (7-12) (7.1, 7.2, 7.3, 7.4, 7.5, 8.1, 8.2, 9.1, 9.2, 9.3, 10.1, 10.2, 11.1/hERG, 11.2, 11.3, 12.1, 12.2, 12.3)
Kvβ (1, 2, 3) • KCNIP (1, 2, 3, 4) • minK/ISK • MiRP (1, 2, 3) • Shaker gene
Kir (1.1, 2.1, 2.2, 2.3, 2.4) • GIRK/Kir (3.1, 3.2, 3.3, 3.4) • Kir (4.1, 4.2, 5.1, 6.1, 6.2, 7.1)
K2P (1, 2, 3, 4, 5, 6, 7, 9, 10, 12, 13, 15, 16, 17, 18)
M+: TRP cation channel
TRPA (1) • TRPC (1, 2, 3, 4, 4AP, 5, 6, 7) • TRPM (1, 2, 3, 4, 5, 6, 7, 8) • TRPML (1, 2, 3) • TRPP (1, 2) • TRPV (1, 2, 3, 4, 5, 6)
Cl-: Chloride channel
CFTR • CLCA (1, 2, 3, 4) • CLCN (1, 2, 3, 4, 5, 6, 7, KA, KB) • CLIC (1, 2, 3, 4, 5, 6) • CLNS (1A, 1B)
Cyclic nucleotide-gated
α1, α2, α3, α4, β1, β3, H1, H2, H3, H4
Porin
Other/general
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