Cation channels of sperm: This small family of ion channels, normally referred to as Catsper channels or CatSper, is related to the two-pore channels and distantly related to TRP channels. The four members of this family form voltage-gated Ca2+ channels that seem to be specific to sperm. These channels are required for proper fertilization. The study of these channels has been slow because they do not traffic to the cell membrane in many heterologous systems.
See also
External links
|
Membrane transport protein: ion channels |
|
| Ca2+: Calcium channel |
|
|
L-type/ Cavα ( 1.1, 1.2, 1.3, 1.4) • N-type/ Cavα2.2 • P-type/ Cavα( 2.1) • Q-type/ Cavα2.1 • R-type/ Cavα2.3 • T-type/ Cavα( 3.2)
α2δ-subunits ( 1, 2) • β-subunits ( β1, β2, β3, β4) • γ-subunits ( γ1, γ2, γ3, γ4)
|
|
|
Other
|
|
|
|
| Na+: Sodium channel |
|
|
Navα ( 1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.8, 1.9, 7A) • Navβ ( 1, 2, 3, 4)
|
|
|
Other
|
|
|
|
| K+: Potassium channel |
|
|
Kvα (1-6) ( 1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.10, 2.1, 2.2, 3.1, 3.2, 3.3, 3.4, 4.1, 4.2, 4.3, 5.1, 6.1, 6.2, 6.3, 6.4)
Kvα (7-12) ( 7.1, 7.2, 7.3, 7.4, 7.5, 8.1, 8.2, 9.1, 9.2, 9.3, 10.1, 10.2, 11.1/hERG, 11.2, 11.3, 12.1, 12.2, 12.3)
Kvβ ( 1, 2, 3) • KCNIP ( 1, 2, 3, 4) • minK/ISK • MiRP ( 1, 2, 3) • Shaker gene
|
|
|
|
Kir ( 1.1, 2.1, 2.2, 2.3, 2.4) • GIRK/ Kir ( 3.1, 3.2, 3.3, 3.4) • Kir ( 4.1, 4.2, 5.1, 6.1, 6.2, 7.1)
|
|
|
|
K2P ( 1, 2, 3, 4, 5, 6, 7, 9, 10, 12, 13, 15, 16, 17, 18)
|
|
|
| M+: TRP cation channel |
TRPA ( 1) • TRPC ( 1, 2, 3, 4, 4AP, 5, 6, 7) • TRPM ( 1, 2, 3, 4, 5, 6, 7, 8) • TRPML ( 1, 2, 3) • TRPP ( 1, 2) • TRPV ( 1, 2, 3, 4, 5, 6)
|
|
| Cl-: Chloride channel |
CFTR • CLCA ( 1, 2, 3, 4) • CLCN ( 1, 2, 3, 4, 5, 6, 7, KA, KB) • CLIC ( 1, 2, 3, 4, 5, 6) • CLNS ( 1A, 1B)
|
|
| Cyclic nucleotide-gated |
|
|
| Porin |
|
|
| Other/general |
|
|
|
