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Fibroblast growth factor 1
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Fibroblast growth factor 1 (acidic)
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| PDB rendering based on 1afc. |
| Available structures: 1afc, 1axm, 1bar, 1djs, 1dzc, 1dzd, 1e0o, 1evt, 1hkn, 1jqz, 1jt3, 1jt4, 1jt5, 1jt7, 1jtc, 1jy0, 1k5u, 1k5v, 1m16, 1nzk, 1p63, 1pzz, 1q03, 1q04, 1rg8, 1rml, 1ry7, 1yto, 1z2v, 1z4s, 2afg, 2aqz, 2axm, 2erm, 2j3p |
| Identifiers |
| Symbols |
FGF1; AFGF; ECGF; ECGF-beta; ECGFA; ECGFB; FGF-alpha; FGFA; GLIO703; HBGF1 |
| External IDs |
OMIM: 131220 MGI: 95515 HomoloGene: 625 |
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| RNA expression pattern |
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More reference expression data
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| Orthologs |
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Human |
Mouse |
| Entrez |
2246 |
14164 |
| Ensembl |
ENSG00000113578 |
ENSMUSG00000036585 |
| Uniprot |
P05230 |
Q6ZWS1 |
| Refseq |
NM_000800 (mRNA)
NP_000791 (protein) |
NM_010197 (mRNA)
NP_034327 (protein) |
| Location |
Chr 5: 141.95 - 142.05 Mb |
Chr 18: 38.97 - 39.04 Mb |
| Pubmed search |
[1] |
[2] |
Fibroblast growth factor 1 (acidic), also known as FGF1, is a human gene.
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein functions as a modifier of endothelial cell migration and proliferation, as well as an angiogenic factor. It acts as a mitogen for a variety of mesoderm- and neuroectoderm-derived cells in vitro, thus is thought to be involved in organogenesis. Three alternatively spliced variants encoding different isoforms have been described.[1]
See also
References
Further reading
- Yu YL, Kha H, Golden JA, et al. (1992). "An acidic fibroblast growth factor protein generated by alternate splicing acts like an antagonist.". J. Exp. Med. 175 (4): 1073–80. PMID 1372643.
- Chiu IM, Wang WP, Lehtoma K (1990). "Alternative splicing generates two forms of mRNA coding for human heparin-binding growth factor 1.". Oncogene 5 (5): 755–62. PMID 1693186.
- Zhu X, Komiya H, Chirino A, et al. (1991). "Three-dimensional structures of acidic and basic fibroblast growth factors.". Science 251 (4989): 90–3. PMID 1702556.
- Wang WP, Quick D, Balcerzak SP, et al. (1991). "Cloning and sequence analysis of the human acidic fibroblast growth factor gene and its preservation in leukemia patients.". Oncogene 6 (9): 1521–9. PMID 1717925.
- Wu DQ, Kan MK, Sato GH, et al. (1991). "Characterization and molecular cloning of a putative binding protein for heparin-binding growth factors.". J. Biol. Chem. 266 (25): 16778–85. PMID 1885605.
- Crumley G, Dionne CA, Jaye M (1990). "The gene for human acidic fibroblast growth factor encodes two upstream exons alternatively spliced to the first coding exon.". Biochem. Biophys. Res. Commun. 171 (1): 7–13. PMID 2393407.
- Harper JW, Strydom DJ, Lobb RR (1986). "Human class 1 heparin-binding growth factor: structure and homology to bovine acidic brain fibroblast growth factor.". Biochemistry 25 (14): 4097–103. PMID 2427112.
- Winkles JA, Friesel R, Burgess WH, et al. (1987). "Human vascular smooth muscle cells both express and respond to heparin-binding growth factor I (endothelial cell growth factor).". Proc. Natl. Acad. Sci. U.S.A. 84 (20): 7124–8. PMID 2444975.
- Wang WP, Lehtoma K, Varban ML, et al. (1989). "Cloning of the gene coding for human class 1 heparin-binding growth factor and its expression in fetal tissues.". Mol. Cell. Biol. 9 (6): 2387–95. PMID 2474753.
- Mergia A, Tischer E, Graves D, et al. (1989). "Structural analysis of the gene for human acidic fibroblast growth factor.". Biochem. Biophys. Res. Commun. 164 (3): 1121–9. PMID 2590193.
- Jaye M, Howk R, Burgess W, et al. (1986). "Human endothelial cell growth factor: cloning, nucleotide sequence, and chromosome localization.". Science 233 (4763): 541–5. PMID 3523756.
- Gimenez-Gallego G, Conn G, Hatcher VB, Thomas KA (1986). "The complete amino acid sequence of human brain-derived acidic fibroblast growth factor.". Biochem. Biophys. Res. Commun. 138 (2): 611–7. PMID 3527167.
- Gautschi P, Fràter-Schröder M, Böhlen P (1986). "Partial molecular characterization of endothelial cell mitogens from human brain: acidic and basic fibroblast growth factors.". FEBS Lett. 204 (2): 203–7. PMID 3732516.
- Gautschi-Sova P, Müller T, Böhlen P (1986). "Amino acid sequence of human acidic fibroblast growth factor.". Biochem. Biophys. Res. Commun. 140 (3): 874–80. PMID 3778488.
- Gimenez-Gallego G, Conn G, Hatcher VB, Thomas KA (1986). "Human brain-derived acidic and basic fibroblast growth factors: amino terminal sequences and specific mitogenic activities.". Biochem. Biophys. Res. Commun. 135 (2): 541–8. PMID 3964259.
- Zhao XM, Yeoh TK, Hiebert M, et al. (1993). "The expression of acidic fibroblast growth factor (heparin-binding growth factor-1) and cytokine genes in human cardiac allografts and T cells.". Transplantation 56 (5): 1177–82. PMID 7504343.
- Pineda-Lucena A, Jiménez MA, Nieto JL, et al. (1994). "1H-NMR assignment and solution structure of human acidic fibroblast growth factor activated by inositol hexasulfate.". J. Mol. Biol. 242 (1): 81–98. doi:10.1006/jmbi.1994.1558. PMID 7521397.
- Chotani MA, Payson RA, Winkles JA, Chiu IM (1995). "Human fibroblast growth factor 1 gene expression in vascular smooth muscle cells is modulated via an alternate promoter in response to serum and phorbol ester.". Nucleic Acids Res. 23 (3): 434–41. PMID 7533902.
- Opalenik SR, Shin JT, Wehby JN, et al. (1995). "The HIV-1 TAT protein induces the expression and extracellular appearance of acidic fibroblast growth factor.". J. Biol. Chem. 270 (29): 17457–67. PMID 7542239.
- Myers RL, Payson RA, Chotani MA, et al. (1993). "Gene structure and differential expression of acidic fibroblast growth factor mRNA: identification and distribution of four different transcripts.". Oncogene 8 (2): 341–9. PMID 7678925.
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