Granulosa cell tumo(u)rs (or granulosa-theca cell tumo(u)rs) are tumors of the granulosa cell. They are part of the sex cord-stromal tumour group of ovarian neoplasms.
The peak age at which they occur is 50-55 years, but they may occur at any age.
Clinical presentation
Estrogens are produced by functioning tumours, and the clinical presentation depends on the patient's age.
Histology
The most characteristic gross appearance is a smooth surfaced solid and cystic lesion with the cysts filled with blood. Hemoperitoneum is an infrequent but classical presentation. A large variety of histological presentations exists, but they have two key features:
- Call-Exner bodies (granulosa cells arranged haphazardly around a space containing eosinophilic fluid); and
- Pale uniform nuclei, often with grooves
There have been cases where the tumor presented as a single, cyst-like, space, with no internal bleeding.
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