The initialism HLA can stand for:

Biochemistry

• Human leukocyte antigen, a key part of the human immune system, or the paternity test based upon it
• Hyaluronic Acid, an important molecule that plays a role throughout the body's skin and connective tissues.

Computing

• High Level Architecture (simulation), a distributed computer simulation standard
• High Level Assembly, an Intel 80x86 Assembly Language, originally written as a teaching aide by Randall Hyde.
• High-level assembler, a generic term for assembly language translators that incorporate features found in modern high-level programming languages into an assembler.

Education

• Houston Learning Academy, an alternative summer education program to redeem or gain credits for the completion of a high school diploma in Houston, Texas.

Engineering

• Hydraulic Lash Adjuster, a device for maintaining zero valve clearance in an internal combustion engine.
• Hydraulic Launch Assist, a hybrid powertrain used on heavy duty vehicles.

Misc

• Hapag-Lloyd Airlines, a German charter airline
• Hidden Lake Academy, a boarding school
• Home Location Area
• Hot Lesbian Action

People

• Harvey L. Atwater, a U.S. politician
• Henry Louis Aaron, a baseball player

Politics

• House of Lords Act, a UK constitutional reform
• Human Life Amendment, a proposed constitutional prohibition of abortion in the United States

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