Mucin 1, cell surface associated
PDB rendering based on 2acm.
Available structures: 2acm
Identifiers
Symbols	MUC1; EMA; CD227; H23AG; MAM6; PEM; PEMT; PUM
External IDs	OMIM: 158340 MGI: 97231 HomoloGene: 8416
Gene ontology Molecular function: • actin binding • hormone activity Cellular component: • extracellular region • cytoskeleton • integral to plasma membrane • membrane • integral to membrane
RNA expression pattern
More reference expression data
Orthologs
	Human	Mouse
Entrez	4582	17829
Ensembl	ENSG00000185499	ENSMUSG00000042784
Uniprot	P15941	Q99K60
Refseq	NM_001018021 (mRNA) NP_001018021 (protein)	NM_013605 (mRNA) NP_038633 (protein)
Location	Chr 1: 153.39 - 153.43 Mb	Chr 3: 89.31 - 89.32 Mb
Pubmed search	[1]	[2]

Mucin 1, cell surface associated, also known as MUC1, is a human gene.

This gene is a member of the mucin family and encodes a membrane bound, glycosylated phosphoprotein. The protein is anchored to the apical surface of many epithelia by a transmembrane domain, with the degree of glycosylation varying with cell type. It also includes a 20 aa variable number tandem repeat (VNTR) domain, with the number of repeats varying from 20 to 120 in different individuals. The protein serves a protective function by binding to pathogens and also functions in a cell signaling capacity. Overexpression, aberrant intracellular localization, and changes in glycosylation of this protein have been associated with carcinomas. Multiple alternatively spliced transcript variants that encode different isoforms of this gene have been reported, but the full-length nature of only some has been determined.^[1]

See also

• Cluster of differentiation
• Mucin

References

Further reading

External links

• MeSH MUC1+protein,+human

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.