PPAT

PPAT

phosphoribosyl pyrophosphate amidotransferase

Identifiers

Symbol PPAT

Entrez 5471

HUGO 9238

OMIM 172450

RefSeq NM_002703

UniProt Q06203

Other data

EC number 2.4.2.14

Locus Chr. 4 pter-q21

Amidophosphoribosyltransferase (or phosphoribosyl pyrophosphate amidotransferase) is an enzyme which converts phosphoribosylpyrophosphate (PRPP) into 5-phosphoribosylamine. The enzyme uses the ammonia group from the glutamine side chain

PRPP	5-phosphoribosylamine

External links

MeSH Amidophosphoribosyltransferase

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v • d • e

Transferases: glycosyltransferases (EC 2.4)

2.4.1 - Hexosyltransferases

2.4.2 - Pentosyltransferases

ADP ribose	Cholera toxin - Diphtheria toxin - Pertussis toxin - Poly ADP ribose polymerase

Other	Purine nucleoside phosphorylase - Adenine phosphoribosyltransferase - Hypoxanthine-guanine phosphoribosyltransferase - Uracil phosphoribosyltransferase - Amidophosphoribosyltransferase - Xylosyltransferase

v • d • e

Metabolism: amino acid metabolism - nucleotide enzymes

Purine metabolism

Anabolism	R5P->IMP: Ribose-phosphate diphosphokinase - Amidophosphoribosyltransferase - Phosphoribosylglycinamide formyltransferase - AIR synthetase (FGAM cyclase) - Phosphoribosylaminoimidazole carboxylase - Phosphoribosylaminoimidazolesuccinocarboxamide synthase - IMP synthase IMP->AMP: Adenylosuccinate synthase - Adenylosuccinate lyase - reverse (AMP deaminase) IMP->GMP: IMP dehydrogenase - GMP synthase - reverse (GMP reductase)

Nucleotide salvage	Hypoxanthine-guanine phosphoribosyltransferase - Adenine phosphoribosyltransferase

Catabolism	Adenosine deaminase - Purine nucleoside phosphorylase - Guanine deaminase - Xanthine oxidase - Urate oxidase

Pyrimidine metabolism

Anabolism	CAD (Carbamoyl phosphate synthase II, Aspartate carbamoyltransferase, Dihydroorotase) Dihydroorotate dehydrogenase - Orotidine 5'-phosphate decarboxylase/Uridine monophosphate synthetase CTP synthase

Catabolism	Dihydropyrimidine dehydrogenase - Dihydropyrimidinase/DPYS - Beta-ureidopropionase/UPB1

Deoxyribonucleotides

Ribonucleotide reductase - Nucleoside-diphosphate kinase - DCMP deaminase - Thymidylate synthase - Dihydrofolate reductase

see also disorders, intermediates