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SLC1A1 

Solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
Identifiers
Symbols SLC1A1; EAAC1; EAAT3
External IDs OMIM: 133550 MGI: 105083 HomoloGene: 20881
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 6505 20510
Ensembl ENSG00000106688 ENSMUSG00000024935
Uniprot P43005 Q6P1F7
Refseq NM_004170 (mRNA)
NP_004161 (protein)		 XM_001002136 (mRNA)
XP_001002136 (protein)
Location Chr 9: 4.48 - 4.58 Mb Chr 19: 28.9 - 28.98 Mb
Pubmed search [1] [2]

Solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1, also known as SLC1A1, is a human gene.[1]


See also

References

  1. ^ "Entrez Gene: SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1".

Further reading

  • Nieoullon A, Canolle B, Masmejean F, et al. (2006). "The neuronal excitatory amino acid transporter EAAC1/EAAT3: does it represent a major actor at the brain excitatory synapse?". J. Neurochem. 98 (4): 1007–18. doi:10.1111/j.1471-4159.2006.03978.x. PMID 16800850. 
  • Arriza JL, Fairman WA, Wadiche JI, et al. (1994). "Functional comparisons of three glutamate transporter subtypes cloned from human motor cortex.". J. Neurosci. 14 (9): 5559–69. PMID 7521911. 
  • Shashidharan P, Huntley GW, Meyer T, et al. (1995). "Neuron-specific human glutamate transporter: molecular cloning, characterization and expression in human brain.". Brain Res. 662 (1-2): 245–50. PMID 7859077. 
  • Kanai Y, Stelzner M, Nussberger S, et al. (1994). "The neuronal and epithelial human high affinity glutamate transporter. Insights into structure and mechanism of transport.". J. Biol. Chem. 269 (32): 20599–606. PMID 7914198. 
  • Smith CP, Weremowicz S, Kanai Y, et al. (1994). "Assignment of the gene coding for the human high-affinity glutamate transporter EAAC1 to 9p24: potential role in dicarboxylic aminoaciduria and neurodegenerative disorders.". Genomics 20 (2): 335–6. doi:10.1006/geno.1994.1183. PMID 8020993. 
  • Zerangue N, Kavanaugh MP (1997). "Interaction of L-cysteine with a human excitatory amino acid transporter.". J. Physiol. (Lond.) 493 ( Pt 2): 419–23. PMID 8782106. 
  • Bar-Peled O, Ben-Hur H, Biegon A, et al. (1997). "Distribution of glutamate transporter subtypes during human brain development.". J. Neurochem. 69 (6): 2571–80. PMID 9375691. 
  • He Y, Janssen WG, Rothstein JD, Morrison JH (2000). "Differential synaptic localization of the glutamate transporter EAAC1 and glutamate receptor subunit GluR2 in the rat hippocampus.". J. Comp. Neurol. 418 (3): 255–69. PMID 10701825. 
  • Lin CI, Orlov I, Ruggiero AM, et al. (2001). "Modulation of the neuronal glutamate transporter EAAC1 by the interacting protein GTRAP3-18.". Nature 410 (6824): 84–8. doi:10.1038/35065084. PMID 11242046. 
  • Veenstra-VanderWeele J, Kim SJ, Gonen D, et al. (2001). "Genomic organization of the SLC1A1/EAAC1 gene and mutation screening in early-onset obsessive-compulsive disorder.". Mol. Psychiatry 6 (2): 160–7. doi:10.1038/sj.mp.4000806. PMID 11317217. 
  • Borre L, Kavanaugh MP, Kanner BI (2002). "Dynamic equilibrium between coupled and uncoupled modes of a neuronal glutamate transporter.". J. Biol. Chem. 277 (16): 13501–7. doi:10.1074/jbc.M110861200. PMID 11823462. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • González MI, Bannerman PG, Robinson MB (2003). "Phorbol myristate acetate-dependent interaction of protein kinase Calpha and the neuronal glutamate transporter EAAC1.". J. Neurosci. 23 (13): 5589–93. PMID 12843260. 
  • Noorlander CW, de Graan PN, Nikkels PG, et al. (2004). "Distribution of glutamate transporters in the human placenta.". Placenta 25 (6): 489–95. doi:10.1016/j.placenta.2003.10.018. PMID 15135231. 
  • Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9.". Nature 429 (6990): 369–74. doi:10.1038/nature02465. PMID 15164053. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Koch HP, Larsson HP (2005). "Small-scale molecular motions accomplish glutamate uptake in human glutamate transporters.". J. Neurosci. 25 (7): 1730–6. doi:10.1523/JNEUROSCI.4138-04.2005. PMID 15716409. 
  • Vallejo-Illarramendi A, Domercq M, Pérez-Cerdá F, et al. (2006). "Increased expression and function of glutamate transporters in multiple sclerosis.". Neurobiol. Dis. 21 (1): 154–64. doi:10.1016/j.nbd.2005.06.017. PMID 16061389. 
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
  • Rainesalo S, Keränen T, Saransaari P, Honkaniemi J (2006). "GABA and glutamate transporters are expressed in human platelets.". Brain Res. Mol. Brain Res. 141 (2): 161–5. doi:10.1016/j.molbrainres.2005.08.013. PMID 16198020. 
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.

v • d • e
Membrane proteins, carrier proteins: membrane transport proteins
ABC-transporter
A1, A2, A3, A4, A7, A8, A12, B1

B2-3, B2, B3, B4, B5, B6, B7, B9, B11

C1, C2, C3, C4, C5, C6, C8, C8-9, C10, C13, C11

D1, D2, D3, D4, E1, F1, F2

G1, G2, G4, Sterolin (G5, G8)
Solute carrier
1A1-7, 1A1, 1A2, 1A3, 1A4, 1A5, 2A1, 2A2, 2A3, 2A4, 2A5, 2A6, 2A8, 2A9, 2A10, 2A12, 3A1, 3A2, 4A1, 4A2, 4A3, 4A4, 4A5, 4A7, 4A8, 4A11, 5A1-2, 5A1, 5A3, 5A5, 5A8, 6A1, 6A2, 6A3, 6A4, 6A5, 6A8, 6A9, 6A19, 7A1, 7A2, 7A3, 7A4, 7A5, 7A7, 7A8, 7A9, 7A11, 8A1-3, 9A1, 9A2, 9A3, 9A3R1, 9A3R2, 9A5, 9A6, 9A8, 10A1, 10A2, 10A3, 10A7, 11A1, 11A2, 11A3, 12A1-2, 12A3, 12A4, 12A5, 12A6, 12A7, 14A1, 13A3, 14A2, 15A1, 15A2, 16A1, 16A2, 16A3, 16A4, 17A1, 17A5, 17A6-8, 17A7, 18A1, 18A2, 18A3, 19A1, 19A2, 19A3, 20A1, 20A2, 22A1, 22A2, 22A3, 22A4, 22A5, 22A6, 22A7, 22A9, 22A11, 22A12, 22A18, 23A1, 23A2, 24A1-2, 24A5, 25A1, 25A3, 25A4, 25A4-6, 25A8, 25A10, 25A11, 25A12, 25A13, 25A14, 25A15, 25A17, 25A19, 25A20, 25A27, 25A31, 25A37, 25A39, 26A2, 26A3, 26A4, 26A5, 26A6, 26A7, 26A8, 27A1, 27A2, 27A3, 27A4, 28A1, 28A2, 29A1, 29A2, 29A4, 30A4, 30A7, 30A8, 31A1, 31A2, 32A1, 34A1, 34A2, 34A3, 35A1, 35A2, 35B2, 35B4, 35C1, 36A1, 37A4, 38A2, 38A3, 39A1, 39A2, 39A3, 39A4, 39A6, 39A7, 40A1, 43A1 44A1, 44A2, 44A4, 45A2, O1A2, O1B1, O1B3, O2B1, O431, O4A1
Monosaccharide
Other
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