SLC2A9

SLC2A9

Solute carrier family 2 (facilitated glucose transporter), member 9

Identifiers

Symbols SLC2A9; GLUT9; GLUTX

External IDs OMIM: 606142 MGI: 2152844 HomoloGene: 69290

Gene ontology

Molecular function: • transporter activity
• sugar:hydrogen ion symporter activity
• glucose transmembrane transporter activity

Cellular component: • nuclear envelope
• plasma membrane
• integral to plasma membrane
• membrane
• integral to membrane

Biological process: • carbohydrate transport
• glucose transport

RNA expression pattern

More reference expression data

Orthologs

Human Mouse

Entrez 56606 117591

Ensembl ENSG00000109667 ENSMUSG00000005107

Uniprot Q9NRM0 n/a

Refseq NM_001001290 (mRNA)
NP_001001290 (protein) NM_001012363 (mRNA)
NP_001012363 (protein)

Location Chr 4: 9.44 - 9.65 Mb Chr 5: 38.64 - 38.79 Mb

Pubmed search [1] [2]

Solute carrier family 2 (facilitated glucose transporter), member 9, also known as SLC2A9, is a human gene.^[1]

This gene encodes a member of the SLC2A facilitative glucose transporter family. Members of this family play a significant role in maintaining glucose homeostasis. The encoded protein may play a role in the development and survival of chondrocytes in cartilage matrices. Two transcript variants encoding distinct isoforms have been identified for this gene.^[1]

SLC2A9 has also recently been found to transport uric acid and genetic variants of the transporter have been linked to increased risk of development of gout.^[2]^[3]

References

^ ^a ^b "Entrez Gene: SLC2A9 solute carrier family 2 (facilitated glucose transporter), member 9".
^ Vitart V, Rudan I, Hayward C, et al (2008). "SLC2A9 is a newly identified urate transporter influencing serum urate concentration, urate excretion and gout". Nature Genetics 40 (4). doi:10.1038/ng.106.
^ Döring A, Gieger C, Mehta D, et al (2008). "SLC2A9 influences uric acid concentrations with pronounced sex-specific effects". Nature Genetics 40 (4). doi:10.1038/ng.107.

Phay JE, Hussain HB, Moley JF (2000). "Cloning and expression analysis of a novel member of the facilitative glucose transporter family, SLC2A9 (GLUT9).". Genomics 66 (2): 217–20. doi:10.1006/geno.2000.6195. PMID 10860667.
Doege H, Bocianski A, Joost HG, Schürmann A (2001). "Activity and genomic organization of human glucose transporter 9 (GLUT9), a novel member of the family of sugar-transport facilitators predominantly expressed in brain and leucocytes.". Biochem. J. 350 Pt 3: 771–6. PMID 10970791.
Shikhman AR, Brinson DC, Valbracht J, Lotz MK (2001). "Cytokine regulation of facilitated glucose transport in human articular chondrocytes.". J. Immunol. 167 (12): 7001–8. PMID 11739520.
Mobasheri A, Neama G, Bell S, et al. (2002). "Human articular chondrocytes express three facilitative glucose transporter isoforms: GLUT1, GLUT3 and GLUT9.". Cell Biol. Int. 26 (3): 297–300. doi:10.1006/cbir.2001.0850. PMID 11991658.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Richardson S, Neama G, Phillips T, et al. (2003). "Molecular characterization and partial cDNA cloning of facilitative glucose transporters expressed in human articular chondrocytes; stimulation of 2-deoxyglucose uptake by IGF-I and elevated MMP-2 secretion by glucose deprivation.". Osteoarthr. Cartil. 11 (2): 92–101. PMID 12554125.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Augustin R, Carayannopoulos MO, Dowd LO, et al. (2004). "Identification and characterization of human glucose transporter-like protein-9 (GLUT9): alternative splicing alters trafficking.". J. Biol. Chem. 279 (16): 16229–36. doi:10.1074/jbc.M312226200. PMID 14739288.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

v • d • e

Membrane proteins, carrier proteins: membrane transport proteins

ABC-transporter

A1, A2, A3, A4, A7, A8, A12

B1, B2-3, B2, B3, B4, B5, B6, B7, B9, B11

C1, C2, C3, C4, C5, C6, C8, C8-9, C10, C13, C11

D1, D2, D3, D4, E1, F1, F2

G1, G2, G4, Sterolin (G5, G8)

Solute carrier

1-10	1A1-7, 1A1, 1A2, 1A3, 1A4, 1A5 Glucose transporter: 2A1 (GLUT1), 2A2 (GLUT2), 2A3 (GLUT3), 2A4 (GLUT4), 2A5 (GLUT5), 2A6 (SLC2A6), 2A8 (GLUT8), 2A9, 2A10, 2A12 3A1, 3A2, 4A1, 4A2, 4A3, 4A4, 4A5, 4A7, 4A8, 4A11, 5A1-2, 5A1, 5A3, 5A5, 5A8, 6A1, 6A2, 6A3, 6A4, 6A5, 6A8, 6A9, 6A19, 7A1, 7A2, 7A3, 7A4, 7A5, 7A7, 7A8, 7A9, 7A11, 8A1-3, 9A1, 9A2, 9A3, 9A3R1, 9A3R2, 9A5, 9A6, 9A8, 10A1, 10A2, 10A3, 10A7

11-20	11A1, 11A2, 11A3, 12A1-2, 12A3, 12A4, 12A5, 12A6, 12A7, 14A1, 13A3, 14A2, 15A1, 15A2, 16A1, 16A2, 16A3, 16A4, 17A1, 17A5, 17A6-8, 17A7, 18A1, 18A2, 18A3, 19A1, 19A2, 19A3, 20A1, 20A2

21-30	22A1, 22A2, 22A3, 22A4, 22A5, 22A6, 22A7, 22A9, 22A11, 22A12, 22A18, 23A1, 23A2, 24A1-2, 24A5, 25A1, 25A3, 25A4, 25A4-6, 25A8, 25A10, 25A11, 25A12, 25A13, 25A14, 25A15, 25A17, 25A19, 25A20, 25A27, 25A31, 25A37, 25A39, 26A2, 26A3, 26A4, 26A5, 26A6, 26A7, 26A8, 27A1, 27A2, 27A3, 27A4, 28A1, 28A2, 29A1, 29A2, 29A4, 30A4, 30A7, 30A8

31-40	31A1, 31A2, 32A1, 34A1, 34A2, 34A3, 35A1, 35A2, 35B2, 35B4, 35C1, 36A1, 37A4, 38A2, 38A3, 39A1, 39A2, 39A3, 39A4, 39A6, 39A7

41-45	40A1, 43A1 44A1, 44A2, 44A4, 45A2

O	O1A2, O1B1, O1B3, O2B1, O431, O4A1

Other

Amino acid (CD98) - Fatty acid (CD36) - Ion channels - Ion pumps - Mitochondrial membrane transport protein - Neurotransmitter transport proteins - Nuclear (Importin, Karyopherin)

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See also

References

Further reading