Sertoli_cell_only

Sertoli cell only syndrome

Sertoli cell-only syndrome
Classification and external resources

OMIM 305700

DiseasesDB 31907

eMedicine med/2104

MeSH D054331

Sertoli cell-only syndrome (a.k.a. Del Castillo syndrome and germ cell aplasia^[1]) is a disorder characterized by male sterility without sexual abnormality. It is the result of absent seminiferous tubules in the testes of germinal epithelium, while Sertoli cells are present.^[2]

1 Features
2 Diagnosis
3 Pathophysiology
4 Treatment
5 Epidemiology
6 References

Features

The Sertoli cell-only syndrome patients normally have normal secondary male features and have normal- or small-sized testes.

Diagnosis

Pathophysiology

Treatment

Sertoli cell only syndrome is like other non-obstructive azoospermia (NOA) cases are manged by sperm retrieval through testicular sperm extraction (mTESE), micro-surgical testicular sperm extraction (mTESE) , or testicular biopsy ^[3]. On retrieval of viable sperms this could be used in Intracytoplasmic Sperm injection ICSI

Epidemiology

References

^ E-Medicine
^ Online Medical Dictionary. [1].
^ Pubmed

v • d • e

Endocrine pathology: endocrine diseases (E00-35, 240-259)

Pancreas/
glucose
metabolism

Diabetes mellitus types: (type 1, type 2, MODY), complications: (coma, angiopathy, ketoacidosis, nephropathy, neuropathy, retinopathy)
Hypoglycemia - Hyperinsulinism - Zollinger-Ellison syndrome - insulin receptor (Rabson-Mendenhall syndrome) - Insulin resistance

Hypothalamic/
pituitary axes

Pituitary	Hyperpituitarism (Acromegaly, Hyperprolactinaemia, SIADH) Hypopituitarism (Sheehan's syndrome, Kallmann syndrome, Growth hormone deficiency, Diabetes insipidus) Adiposogenital dystrophy - Empty sella syndrome - Pituitary apoplexy - ACTH deficiency

Thyroid	Hypothyroidism (Iodine deficiency, Cretinism, Congenital hypothyroidism, Goitre, Myxedema) Hyperthyroidism (Graves disease, Toxic multinodular goitre, Teratoma with thyroid tissue or Struma ovarii) Thyroiditis (De Quervain's thyroiditis, Hashimoto's thyroiditis, Riedel's thyroiditis) Euthyroid sick syndrome - Thyroid hormone resistance - Thyroid nodule

Parathyroid	Hypoparathyroidism (Pseudohypoparathyroidism) - Hyperparathyroidism (Primary, Secondary, Tertiary)

Adrenal	Adrenocortical hyperfunction: Cushing's syndrome (Nelson's syndrome, Pseudo-Cushing's syndrome) - Hyperaldosteronism (Conn syndrome, Bartter syndrome) CAH (Lipoid, 3β, 11β, 17α, 21α) Adrenal insufficiency (Addison's disease, Waterhouse-Friderichsen syndrome) - Hypoaldosteronism

Gonads	ovarian (Polycystic ovary syndrome, Premature ovarian failure) testicular (5-alpha-reductase deficiency, 17-beta-hydroxysteroid dehydrogenase deficiency) general (Hypogonadism, Delayed puberty, Precocious puberty)

Other

Androgen insensitivity syndrome - Autoimmune polyendocrine syndrome - Carcinoid syndrome - Gigantism - Short stature (Laron syndrome, Psychogenic dwarfism) - Multiple endocrine neoplasia (1, 2) - Progeria - Woodhouse-Sakati syndrome - thymus (Abscess of thymus, Thymus hyperplasia)

see also congenital, neoplasia