Stigmine

Stigmine

Pyridostigmine

Stigmine refers to a class of acetylcholinesterase inhibitor.

Examples include:

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v • d • e

Direct
(at receptor)

Indirect/AIs
(in synapse)

Reversible	very short acting: Edrophonium carbamates/stigmine: Ambenonium · Rivastigmine · Distigmine · tertiary/CNS (Physostigmine) · quaternary/peripheral (Neostigmine, Pyridostigmine) anti-dementia (Galantamine, Donepezil, Tacrine)

Irreversible/ organophosphate	ophthalmological (Ecothiopate, Isoflurophate, Demecarium) antiparasitic (Malathion, Metrifonate) chemical warfare (see Nerve agent)

v • d • e

Direct
(at receptor)

Indirect/AIs
(in synapse)

Reversible	very short acting: Edrophonium carbamates/stigmine: Ambenonium · Rivastigmine · Distigmine · tertiary/CNS (Physostigmine) · quaternary/peripheral (Neostigmine, Pyridostigmine) anti-dementia (Galantamine, Donepezil, Tacrine)

Irreversible/ organophosphate	ophthalmological (Ecothiopate, Isoflurophate, Demecarium) antiparasitic (Malathion, Metrifonate) chemical warfare (see Nerve agent)

v • d • e Ophthalmologicals: antiglaucoma preparations and miotics (S01E)

Sympathomimetics	Apraclonidine • Brimonidine • Clonidine • Dipivefrine • Epinephrine

Parasympathomimetics	M: Aceclidine • Pilocarpine M/N: Acetylcholine • Carbachol AI: Demecarium • Ecothiopate • Stigmine (Fluostigmine, Neostigmine, Physostigmine) • Paraoxon

Carbonic anhydrase inhibitors	Acetazolamide • Brinzolamide • Diclofenamide • Dorzolamide • Methazolamide

Beta blocking agents	Befunolol • Betaxolol • Carteolol • Levobunolol • Metipranolol • Timolol

Prostaglandin analogues	Bimatoprost • Latanoprost • Travoprost • Unoprostone

Other agents	Dapiprazole • Guanethidine