Theodor Heinrich Boveri (October 12, 1862–October 15, 1915) was a German biologist whose work with sea urchins showed that it was necessary to have all chromosomes present in order for proper embryonic development to take place. This discovery was an important part of the Boveri-Sutton chromosome theory. His other significant discovery was the centrosome (1888), which he described as the especial organ of cell division. Boveri also had discovered a phenomenon of chromatin diminution in early embryonic development of nematode Parascaris.
He also reasoned that a cancerous tumor begins with a single cell in which the make up of its chromosomes becomes scrambled, causing the cells to divide uncontrollably.
It was only much later in the twentieth century that leading researchers came to believe that Boveri may have been correct.
References
- Baltzer, Fritz (1967), Theodor Boveri: The Life of a Great Biologist 1862-1915, <http://www.devbio.com/article.php?ch=7&id=75>. Retrieved on 22 July 2007 . Extract published in Gilbert, SF (2006), DevBio: a companion to Developmental Biology, 8th ed., Sinauer Associates
- Boveri, Theodor (2008), “Concerning The Origin of Malignant Tumours”, Journal of Cell Science 121 (Supplement 1): 1–84, <http://jcs.biologists.org/cgi/content/full/121/Supplement_1/1>
- Maderspacher, Florian (2008), “Theodor Boveri and the natural experiment”, Current Biology 18 (7): R279–R286, DOI 10.1016/j.cub.2008.02.061
- Satzinger, Helga (Mar. 2008). "Theodor and Marcella Boveri: chromosomes and cytoplasm in heredity and development". Nat. Rev. Genet. 9 (3): 231–8. doi:10.1038/nrg2311. PMID 18268510.
- Laubichler, Manfred D; Davidson Eric H (Feb. 2008). "Boveri's long experiment: sea urchin merogones and the establishment of the role of nuclear chromosomes in development". Dev. Biol. 314 (1): 1–11. doi:10.1016/j.ydbio.2007.11.024. PMID 18163986.
- Bignold, Leon P; Coghlan Brian L D, Jersmann Hubertus P A (Jul. 2006). "Hansemann, Boveri, chromosomes and the gametogenesis-related theories of tumours". Cell Biol. Int. 30 (7): 640–4. doi:10.1016/j.cellbi.2006.04.002. PMID 16753311.
- Hardy, Paul A; Zacharias Helmut (Dec. 2005). "Reappraisal of the Hansemann-Boveri hypothesis on the origin of tumors". Cell Biol. Int. 29 (12): 983–92. doi:10.1016/j.cellbi.2005.10.001. PMID 16314117.
- Wunderlich, Volker (Sep. 2002). "JMM---past and present. Chromosomes and cancer: Theodor Boveri's predictions 100 years later". J. Mol. Med. 80 (9): 545–8. doi:10.1007/s00109-002-0374-y. PMID 12226736.
- Manchester, K L (Jul. 1997). "Overlooked Nobel laureates". Adler Museum bulletin 23 (2): 20–1. PMID 11619485.
- Manchester, K (. 1997). "The quest by three giants of science for an understanding of cancer". Endeavour 21 (2): 72–6. doi:10.1016/S0160-9327(97)01030-2. PMID 9237430.
- Moritz, K B; Sauer H W (Feb. 1996). "Boveri's contributions to developmental biology--a challenge for today". Int. J. Dev. Biol. 40 (1): 27–47. PMID 8735909.
- BALTZER, F (May. 1964). "Theodor Boveri". Science 144: 809–15. doi:10.1126/science.144.3620.809. PMID 14149391.
- STERN, C (Sep. 1950). "Boveri and the early days of genetics". Nature 166 (4219): 446. doi:10.1038/166446a0. PMID 14775717.
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